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KMID : 1123920110250061000
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 6 p.1000 ~ p.1007
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Effects of Acanthopanax Senticosus and Onion Mixture Extract on the Collagen-induced Arthritis in Rat Model
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Kim Kyung-Yoon
Sim Ki-Cheol
Kim Gye-Yeop
Choi Chan-Hun
Jung Jae-Gon
Chung Jae-Sun
Jung Hyun-Woo
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Abstract
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This study was conducted to determine the analgesic effect of onion and acanthopanax senticosus mixture extract using the rheumatoid arthritis rat model. Rheumatoid arthritis model was made by the intradermal injection of type Ⅱ collagen emulsified. Rats were divided into four groups: (1) Sham group(n=5), (2) Control group(administered DW 3 ㎖/1 day after RA induced, n=7), (3) Experimental group Ⅰ(administered Onion extractor 600 ㎎/3 ㎖/1 day after RA induced, n=7). (4) Experimental group Ⅲ(administered Onion and Acanthopanax senticosus mixture extractor 600 ㎎/3 ㎖/1 day after RA induced, n=7). After that, we examined the arthritic index, paw edema, pain threshold at 1st, 14th, 28th days. And also we examined histopathologic study(safranin-O green), immunohistochamical stain(COX-2) of knee joint at 28th days. Arthritic index, paw edema and pain threshold test were decrease in experimental group Ⅰ,Ⅱ than control group. Especially group Ⅱ was most significantly inhibit effect than the other groups at 28th days. On the histopathologic view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. All experimental groups were COX-2 positive cells in the immunohistological stain of the knee joint were significantly decreased compared with control group. Especially group Ⅱ was most significantly decreased than the other groups at 28th days. Onion and Acanthopanax senticosus mixture extractor can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of Onion and Acanthopanax senticosus.
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KEYWORD
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onion, acanthopanax senticosus, Type II collagen-induced arthritis
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